Postdoctoral Researcher in Computational single-cell biology

Do you want to contribute to top quality medical research?

Description of the research group

A postdoctoral research position is available in the lab of Rickard Sandberg at the institution for Cell and Molecular Biology (CMB). The lab is located in Biomedicum, a top-notch research building with a modern infrastructure and equipment. Rickard’s lab is focusing on developing single-cell technologies to study transcriptional dynamics and how it is encoded within our genomes. To this end, we have developed highly sensitive full-length single-cell RNA-sequencing methods and combined them with 4sU labelling of new RNA in cells, and used these techniques to generate comprehensive new data sets that awaits more in-depth analyses.

Your mission

This postdoctoral research project is focused on computational analyses of transcriptional regulation, with a focus on deciphering how DNA-binding factors regulate transcriptional bursting. It will involve large-scale processing of single-cell RNA-seq and ATAC-seq data, to intersect them to identify DNA-binding factors that significantly shape bursting kinetics. Multiple strategies are being explored, including single-cell burstingQTL analyses and analysis of bursting kinetics after the perturbation of important regulators.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The postdoctoral candidate must have a background in computational biology, including sequencing-based projects and/or single-cell genomics. Meriting is experience in efficient computational strategies for processing large-scale data sets (Tb data; multi-core; Python; Rust) and explorative analyses of single-cell data (incl. biological filtering, separating biological and technical signals, multidimensional projections).

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Stockholm

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

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