Postdoctoral Researcher in cancer research with focus on environmental mutagenesis

Do you want to contribute to top quality medical research?

We are looking for a motivated postdoc to be part of our research group with a focus on mixture toxicology at the Unit of Biochemical Toxicology, Institute of Environmental Medicine (IMM). The position is placed in the research group of Kristian Dreij in a project that aims to determine and evaluate mutational signatures of environmental complex mixtures to improve the understanding of carcinogenesis.

Your mission

Experimentally determined mutational signatures have provided important insights into the agents and processes underlying the causes of human cancer. Although humans mainly are exposed to complex mixtures of agents that might contribute to cancer development, this research has so far exclusively focused on single mutagens. The overall objective of this project is to determine and evaluate mutational signatures induced by environmental complex mixtures in human iPS cells, thereby increasing the understanding of the mechanisms and role of mixtures vs single compounds in cancer etiology. This project is conceptually novel and expected to have important consequences on our understanding of mutational signatures and cancer development.

The post doc will primarily use cellular and molecular biology methodologies together with next-generation sequencing to determine mutational signatures and gene expression profiles in cells exposed to environmental complex mixtures. The post doc will perform bioinformatic analyses of the sequencing data together with collaborators and NBI Sweden. Other tasks include writing manuscripts and participating in meetings and discussions with partners as well as teaching. The position is temporary for 2 years, with possibility of extension.

Your profile

We are looking for a highly motivated postdoctoral fellow who can work independently and develop their own ideas and visions and with a strong drive for a future career in research. The successful applicant must have a Ph.D. from an appropriate discipline such as toxicology, cell- or molecular biology with an in-depth understanding of cellular signaling, mutagenesis and carcinogenesis. Documented experience of working with cell culture and molecular biology techniques is required. Documented experience of performing and analyzing in vitro toxicology experiments is highly meriting. Documented experience of data analysis of next-generation sequencing data is meritorious. The candidate must be able to work well in a team with researchers from different disciplines, have good collaboration and communication skills and must be able to communicate well in English, both orally and in writing. In addition, personal suitability will be a factor in the selection process.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location:

Institute of Environmental Medicine, Solna. For more information:

https://staff.ki.se/people/kristian-dreij

https://ki.se/en/imm/unit-of-biochemical-toxicology

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest xxx

The application is to be submitted through the Varbi recruitment system.

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