Postdoctoral studies employing Bioinformatic gene-expression analysis in Neurobiology (scholarship) - Hiring in process/Finished, not possible to apply

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Division

Division of Clinical Geriatrics consists of a multi-disciplinary team at the forefront of translational Alzheimer's disease (AD) research using cutting-edge technology with aims to develop new diagnostic biomarkers and new treatment strategies in AD. We work in an inter-disciplinary environment which provides ample opportunities to enhance our understanding and skills.

Duties

We are looking for an enthusiastic and highly motivated scientist who is interested in working in a multi-disciplinary team at the forefront of translational AD research. Our group has a lot of experience with therapeutic application in AD targeting the cholinergic pathways, primarily by targeting the neurotrophin – Nerve Growth Factor (NGF) using encapsulated cell (EC Biodelivery) mediated drug delivery or by using cholinesterase inhibitor (ChEI’s) treatment. We want to further our work by performing in-depth gene expression analysis from high-throughput sequencing projects.

We will employ studies involving in-vitro experimentation, preclinical in-vivo set-up, and clinical studies, using various physiological and pathological conditions and study the underlying changes in signaling pathways and cellular behavior through gene expression analysis, in combination with other techniques available in our lab.

This postdoctoral scholarship will involve designing experiment layouts, data management, data analysis and interpretation, manuscript preparation, presenting research, contributing to grant proposals, and mentoring students. The candidate will perform integrated computational analysis of different types of next-generation sequencing data and interpret the results as a member of a team of researchers. You will have the opportunity to publish high-profile papers with a prominent authorship position depending on the intellectual contribution. You have strong enthusiasm for developing collaborative relationships and a desire to foster the use of bioinformatics data in research studies. The environment provides excellent post-doctoral training in an international working environment, with national and international collaborations. You will have the opportunity to network with other bioinformatics researchers through the KI Center for Bioinformatics and Biostatistics.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Candidates must hold a PhD degree, or a foreign qualification deemed equivalent to a doctoral degree in the field of Bioinformatics, Computational Biology, or any related field, with documented experience in working with data analysis of sequencing data such as single-cell RNA-seq, bulk RNA-seq, ChIP-seq, methylation data and possibly micro-array data to investigate genetics in human and mouse diseases.

Documented proficiency in analyzing data from single-cell ATAC-seq and Spatial Transcriptomics would be an asset. The candidate should have an interest in neurodegenerative diseases.

The successful candidate is expected to have established a record of high-quality scientific research documented by research publications, the ability to work both independently and as a member of a collaborative, scientific team, excellent verbal and written English skills, and to write grant applications.

The candidate should have completed his/her PhD degree within four years before the last date of application. Candidates who have completed their degree earlier than this should receive equal priority if special grounds exist.

Location: Flemingsberg

Department of NVS

Division of Clinical Geriatrics

Type of scholarship

Postdoctoral scholarship will be awarded, and the position is available immediately. The duration of the scholarship available is up to 12 months, with the possibility of extension based on performance and availability of funding.

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio
• A complete list of publications
• A summary of current work (no more than one page)
• Verifications for crediting of illness, military service, work for labour unions or student organizations, parental leave or similar circumstances
• Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)

The application is to be submitted on the Varbi recruitment system. Last application date: 2023-08-21.

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