Postdoctoral Researcher in human innate lymphoid cell immunometabolism

Do you want to contribute to improving human health?

We are seeking a motivated and ambitious immunologist to join our team of highly accomplished immunologists based at the Centre for Infectious Medicine (CIM). The research interest is focused on tumor immunology and asthma, specifically the role of human Innate Lymphoid Cells (ILC) immunometabolism. We study how distinct ILC subsets adapt to their local tissue environment and perturbations that are caused by tumour development. Working in close collaboration with group of Professor Jenny Mjösberg, (https://ki.se/en/medh/jenny-mjosberg-group-innate-lymphoid-cells-ilcs ), the team of Dr. Chris Tibbitt offers an engaging and diverse environment where you will contribute towards high quality research (Tibbitt et al., Immunity 2019, Science Immunology 2021, Science Immunology 2017) on an internationally competitive level that involves both basic and translational immunology.

Your mission

Using the latest techniques in metabolic profiling and single-cell sequencing the candidate will map the metabolic profiles of human ILCs and T cells across a range of tissues and inflammatory conditions. The candidate will also perform multi-parameter flow cytometry, immunofluorescence, ELISA, Seahorse, siRNA/ lentiviral ‘knock-downs’ and in vitro cultures using ILCs and T cells extracted from human tissue samples. The individual will work in a multi-disciplinary team environment meaning excellent communications skills are essential.It is expected that the postdoctoral researcher will eventually supervise students and other researchers, as well as contribute to common lab duties.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants must have relevant university education and hold a PhD degree in immunology. There is also a requirement for experience with multiparameter flow cytometry and to have previous experience working with ILCs and T Helper cells. Moreover, knowledge regarding isolation of immune cells from tissues, biobaking of clinical samples, sectoning of FFPE-tissue and OCT-tissue, working with immunohistochemical and immunofluorescence techniques, microscopy is highly recommended. Pratical experience with metabolic assays (e.g. Seahorse, SCENITH, Mitotracker, etc) are a merit. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdiciplinary team. Fluency in English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 2023-05-09

The application is to be submitted through the Varbi recruitment system.

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