Research Assistant - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

Our research group investigates how protein ubiquitylation control cellular integrity and how alterations of components of the ubiquitin-machinery contribute to cancer progression. The research is primarily focused on SCF ubiquitin ligases regulating oncogenic substrates to expose novel cancer vulnerabilities, new drug targets and resistance mechanisms.

Your mission

The successful candidate will be responsible for performing various cell/molecular techniques central to a research project focused on a recently identified SCF ubiquitin ligase regulating DNA replication stress and cancer immune evasion. The work includes theoretical knowledge in bioinformatics, ubiquitin-research, DNA replication/damage/checkpoint regulation and cancer immunology. Practical experience in the above research areas is meriting.

Your profile

To be eligible, an applicant should have a background in cancer research, targeted therapies and bioinformatics with data mining skills. Specifically, entry requirements include;

• Bachelor’s degree in biomedicine, molecular biology, or molecular biotechnology
• Expertise in cell and molecular biology techniques, including cell culture, cell motility/invasion assays, cell cycle/viability assays, flow cytometry, protein purification, RT-qPCR, Western blot, immunoprecipitation, kinase/Elisa assays, siRNA transfection, cloning, CRISPR-knock-out/in design, confocal microscopy.
• Computational/Software and analytical skills: R language, SnapGene, FlowJo, ImageJ, Python, SPM12, VINCI, Linux and basic statistical analysis. Experience in processing of HTP transcriptomic/proteomic data and applied bioinformatics is important (eg GSEA, Survival analysis, gene-dependency analysis).
• Previous work with inhibitor/compound-relevant assays (DNA damage/protein stability/CETSA, FRAP techniques) and in silico modelling is meriting.
• The applicant must speak and write fluent English

We seek a candidate with a genuine interest in studying molecular mechanisms altered in cancer. Excellent interpersonal and organizational skills are required. Emphasis will be placed on qualities as responsibility, flexibility, teamwork and ability to solve problems.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

The length of employment for this employment is up to 9 months.

Location: Solna

--[Video about Karolinska Institutet, how we all work towards "a better health for all"] --

Application

Welcome to apply!

The application must contain the following documents in Swedish or English:

1. Cover letter
2. CV including contact details of at least 2 referees
3. Copy of degree certificates and grades
The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all