Research Specialist in the Epigenetic Control of Atherosclerosis - Hiring in process/Finished, not possible to apply

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, Alzheimer, bioorganic chemistry, biomaterial, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, immunology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in Neo at Campus Flemingsberg, a biomedical research building, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

The position will be placed in the laboratory of Professor Eckardt Treuter which conducts pre-clinical research at the crossroads between epigenomics, metabolism, inflammation and disease. The laboratory is located at the Department of Biosciences and Nutrition, an excellent international research environment performing research in key areas of biomedical science, hosting around 250 scientists, students, administrative and technical personnel.

https://ki.se/en/bionut/epigenetic-mechanisms-underlying-metabolic-inflammatory-diseases-eckardt-treuter

Your mission

You will join our efforts to characterize the function of transcriptional regulators in atherosclerosis, with an emphasis on epigenetic alterations in macrophages and hepatocytes that potentially link type 2 diabetes and liver steatosis/fibrosis, respectively, to the development of cardiovascular diseases.

We will assess the suitability of candidates using the following criteria:

• Handling, manipulation and characterization of atherogenic mouse models.
• Design procedures involving above atherosclerosis models.
• Writing ethical applications to conduct animal experiments.
• In vitro analysis of human monocytes, macrophages and hepatocytes
• Generation and analysis of CUT&Tag/ATAC/RNA-sequencing data, batch and single cell approaches.
• Preparation of manuscripts and grant applications.
• Supervision of undergraduate and PhD students
• Organization of laboratory routines, safety issues and chemical register
• Organization of collaborative networks (including ongoing EU projects).

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

We are looking for an excellent team player with interpersonal skills, organized, efficient, and flexible in dealing with unpredictability and changes. Emphasis will be placed on personal suitability.

Assessment criteria

It is particularly meritorious that the applicant has shown prior experience in generating and characterizing transgenic mouse models; prior knowledge and understanding of metabolism, inflammation, tissue crosstalk, liver and macrophage biology, cardiovascular disease pathways, from mouse to humans; prior experience in the analysis of gene expression pathways, genomic and epigenomic profiling, virus delivery systems, in vitro culture of cell lines and primary tissues, bone marrow-derived macrophages and blood-derived monocytes.

It is additionally meritorious that the applicant has shown prior experience in any of the above outlined specific duties required for this position (e.g. lab management, supervision, publication and application writing, scientific collaborations).

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

https://ki.se/en/bionut/epigenetic-mechanisms-underlying-metabolic-inflammatory-diseases-eckardt-treuter 

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The application must be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all