Postdoctoral Researcher to the Department of Microbiology, Tumor- and Cell biology

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts
research and teaching in immunology, infection biology, cell biology and cancer. Key words are
multidisciplinary, bridging, translational, national and international collaborations.

The Schlisio lab at Karolinska Institute, Sweden, seeks a postdoctoral fellow to work on molecular
principles of tumor formation arising from the sympathoadrenal cell lineage (neuroblastoma,
pheochromocytoma, paraganglioma) to explore cell of origin, disease initiation and tumor heterogeneity.

Your mission

We are seeking a motivated, creative post-doctoral candidate interested in exploring drivers of intratumor heterogeneity and phenotypic plasticity in sympathoadrenal tumors, such as childhood neuroblastoma and pheochromocytoma. Intratumor heterogeneity and high plasticity account for therapy resistance. Causes of plasticity cell state transitions during tumor progression remain poorly understood. Currently, there is no effective treatment that addresses cancer heterogeneity. Systematic characterization of dynamic properties of intratumor heterogeneity and phenotypic plasticity can guide treatment strategies and improve clinical outcome for cancer patients.

We aim at elucidating the origin and heterogeneity of sympathoadrenal malignancies, such as pheochromocytoma and childhood neuroblastoma by developing a new analytic and experimental approach based on single-cell transcriptomics with integrated mass spectrometry. We generated novel tumor mouse model systems and include human tumors to perform comparative differentiation trajectory analysis, to make predictions and, finally, to perform preliminary validations of envisioned tumor differentiation strategies.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Successful applicants must have the following skills:

The applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.
To be eligible for the position, you must have completed your doctoral degree in neuroendocrine cancer research or equivalent as well as FELASA B certificate are required.
Ability to work both independently and collaboratively in a group
Have good English communication skills.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-10-04

The application is to be submitted through the Varbi recruitment system.

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