Postdoctoral Researcher in protein production/molecular biology - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

We are seeking two highly skilled and motivated post-doctoral research fellows in protein production/molecular biology, to join an international open science project in translational medical research. This is an exciting opportunity to work on generating proteins and antibodies to human targets as part of the EUbOPEN project, using a combination of molecular biology, cell biology and biochemistry. We offer a multi-national and collaborative research environment with partners in academia and the biomedical
industry worldwide.

Your mission

Two highly motivated, skilled and experienced post-doctoral research fellows in protein production/molecular biology are needed to work at SGC-Karolinska in our IMI (EU and Pharma) funded EUbOPEN project. You will be part of a research team developing high quality protein affinity reagents. Specifically, you will generate recombinant antibodies using phage display selection and characterize prioritized human proteins, to serve as e.g. tool reagents for assay development, antigens for antibody production, analysis of protein interaction partners and to aid crystallization experiments. You will be integral members of a team which works to generate high quality and renewable antibodies in a high throughput format. The work includes cloning, protein production, phage display selection and cellbased antibody validation. The duties of the position also include reporting and data dissemination (via publications and public data repositories). Thus, your work will contribute to the broader goal of EUbOPEN; to make pharmacological tools to one third of the human druggable genome available to the scientific community without restrictions, as part of the Target 2035 initiative. Although the position is a temporary position longer than 6 months, this is supposed to correspond to up to 24 months if possible.

This large-scale project is a collaboration between Karolinska Institutet, University of Oxford (UK),
Goethe University Frankfurt and other partners in EU, UK and globally, funded by the European Union and pharmaceutical company partners. EUbOPEN is conducted as an integrated project with the Structural Genomics Consortium (SGC). The EUbOPEN organization based at Karolinska Institutet comprises funding for more than 20 staff members and is expected to grow as additional funding becomes available. Overall, EUbOPEN has activities e.g. in structural and chemical biology, antibody production and characterization as well as functional studies of human proteins in disease relevant assays. EUbOPEN is funded until end of April 2025 and the right candidate will have a good chance of extension

Your profile

You have a recent PhD degree in medicine/biomedicine, molecular biology, protein chemistry,
biochemistry, cell biology or other relevant area(s) and a passion for practical laboratory work. You are a flexible problem solver who likes to work collaboratively as well as independently with production, analysis and reporting of data to the project team. Experience from designing and running biochemical assays and characterization of proteins is a merit. Furthermore, you need to be able to communicate well in English, be well-structured and take responsibility to produce well-documented high-quality scientific data.

You should have documented experience with cloning, expression screening and protein production and purification. Experience from mammalian expression of human proteins is a significant merit. Experience with phage display and antibody validation is not required but considered a merit.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective
agreement.

Location:
The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Per-Johan Jakobsson, within the Department of Medicine Solna which since March 2015 is one of the partners of the Structural Genomics Consortium (SGC, www.thesgc.org) and its Innovative Medicines Initiative (EU) projects which in part focus on the discovery and evaluation of novel targets in inflammatory diseases (ULTRA-DD 2015-2020 and EUbOPEN 2020-2025, www.eubopen.org). The position is placed within the SGC-KI research team headed by Michael Sundström (Scientific Director), organized within the group of Professor Per-Johan Jakobsson, Division of Rheumatology, Department of Medicine, Karolinska Institutet, Solna. Part of the work will be carried out in close collaboration with Science for Life Laboratory (www.scilifelab.se). 

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-09-09.

The application is to be submitted through the Varbi recruitment system.

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