Postdoctoral Researcher in lipid bioanalytical chemistry of respiratory disease

Do you want to contribute to improving human health?

Chronic lung disease is one of the largest noncommunicable diseases globally, resulting in upwards of 4 million deaths annually. Eicosanoids and related lipid mediators have been shown to exert causative role in the etiology of severe airway disease. Recent findings have shown that the early life gut microbiome produces lipid mediators associated with the onset of pediatric atopy and asthma. The identification of novel lipid mediators involved in the gut-lung axis therefore represents a novel therapeutic target in treating pediatric lung disease.

Your mission

We have an opening for an individual wishing to join a multidisciplinary project aimed to understand the role of lipid mediators in lung disease. The successful candidate will be expected to use and further develop mass spectrometry-based methods for quantification of lipid mediators including eicosanoids (e.g., prostaglandins, leukotrienes), novel octadecanoids (see https://bit.ly/3xQjr5K) and structural lipids. Analyses will involve further development of novel chromatography approaches including chiral and UPC2 methods for applications in large scale clinical studies as well as experimental models to map the biochemical role of lipid mediators in the pathobiology of lung disease. Functional studies will be performed in multiple cell types, in ex vivo lung tissue as well as in animal models to generate a biochemical map of both pro-inflammatory and pro-resolving lipid mediators. This project will be performed in collaboration with researchers at the University of California San Francisco (UCSF) (see https://bit.ly/3xOnC1S and https://bit.ly/3zA5z0w).

Your profile

We are looking for highly motivated candidates with a Ph.D. in quantitative mass spectrometry or bioanalytical chemistry. The successful candidate will be expected to use and further develop mass spectrometry-based methods for metabolic profiling of lipid mediators. Accordingly, applicants must document their experience in small molecule mass spectrometry by LC-MS/MS as well as familiarity with quantification and method validation. Prior experience working with lipids is considered a merit as well as experience in cell culture and FACS analysis. Excellent communication skills and an ability to interact socially and scientifically with other members of the laboratory and with international collaborators are essential.

Qualification to be employed as a postdoctoral researcher requires having obtained a doctorate or the equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

We offer a creative and inspiring environment with wide-ranging expertise and interests. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers in a new custom designed state-of-the art analytical facility. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement. The successful applicant will belong to the Unit of Integrative Metabolomics in the Institute for Environmental Medicine. This full-time position is temporary (two years), with potential for renewal.

Location: Solna

http://www.metabolomics.se

https://ki.se/en/imm/unit-of-integrative-metabolomics

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply.

The application is to be submitted through the Varbi recruitment system.

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