Senior Research Specialist in Vascular Mechanisms in Neurodegeneration - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

In our research group, you will find a unique opportunity to work closely with top researchers at the interface of vascular biology and neuroscience to jointly understand how the human brain becomes vulnerable during injury, neurodegeneration and aging. Our recent work aims to better understand the cellular mechanisms, biomarkers and genetic risk of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease. We offer an engaging and international research environment where you will have the opportunity to contribute to high quality research at the top international level.

Description of the subject area

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects motor neurons, and for which there is currently no treatment or cure. Identifying factors that contribute to this disease is a major research goal within our group in order to be able to develop an appropriate immunotherapy to target those factors. We are particularly interested in the role of the vasculature in early pathogenesis.

Your mission

We are looking for a senior research specialist with good knowledge of both experimental and human ALS, who also has expertise within vascular biology. The individual will develop and maintain a web resource for ALS transcriptomic data, identify biomarkers and develop a stratification system for patients into distinct subgroups based on comparative analysis of multiple omics and phenotypic data. The work will include design of analysis, data processing, quality control, statistical analyses, data interpretation and presentation of findings in the form of scientific publications, grant applications and at meetings and conferences. The individual is expected to oversee organization of research projects conducted by other postdocs and PhD students. The candidate is expected to interact with many collaborators at Karolinska Institute and externally and to contribute to the efficient functioning of the unit. We offer a very stimulating and welcoming working environment in a unit of motivated co-workers with diverse competencies.

Eligibility requirements

To be eligible for employment as a Senior Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated good level of research expertise with significant scientific production. The applicant must also have demonstrated a good scientific independence to which their own contribution has been significant and a research plan of high quality with clear potential for the future.

We are looking for a candidate with:

• A PhD in molecular biology or bioinformatics with at least 7 year working experience.
• Documented experience with preclinical drug experiments using ALS animal models.
• Substantial transcriptomics expertise in life sciences.
• Excellent analytical and quantitative skills.
• Documented research experience of complex data analysis.
• Excellent knowledge of statistics.
• Ability to deliver high-quality scientific outputs with a strong publication record as first and last author.
• High level of demonstrable communication skills.
• Ability to work independently and take own initiatives.

The candidate should also have good interpersonal skills and the ability to work both independently but also as a part of a large team. Good knowledge of spoken and written English and good communication skills are also required. Experience with writing scientific papers and grant applications is required.

Assessment criteria

For employment as Senior Research Specialist at Karolinska Institutet, the eligibility requirements and assessment criteria stated in the Rules regarding other positions than teaching positions are applied in relation to the established profile of employment.

It is particularly meritorious that the applicant has shown

• Scientific original publications, their quality and quantity, with special consideration on publications after the doctoral education.
• Scientific independent ability demonstrated through leading and senior authorships.
• Review articles and other scientific publications.
• Presentations and scientific assignments at international congresses.
• Research grants received in regional, national and international competition as main applicant.
• National and international research collaborations
• Development of one's own research profile within the subject area.
• Plan for future research based on current science.
• Experiences in one or more of the following areas:
  • Vascular biology
  • Amyotrophic lateral sclerosis
  • Database management
• Documented international collaborative clinical network

It is meritorious that the applicant has shown

• Research responsibility as supervisor for degree project on advanced level, doctoral student and postdoc.
• Reviewer and evaluator of the scientific work of others.
• Research experience from a research group other than where the doctoral education was conducted.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

Read more about the Department of Clinical Neuroscience.
Read more about the research group you will be part of.

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The applications will be reviewed by external reviewers.

Welcome to apply at the latest 2022-02-17.

The application must be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!