Postdoctoral researcher in spinal cord regeneration

Do you want to contribute to top quality medical research?

A postdoctoral position is available in the lab of András Simon at the Department of Cell and Molecular Biology, Karolinska Institutet. The lab seeks to reveal mechanisms that are responsible for successful regeneration to occur in salamanders, and conversely, highlight processes that prevent comparable injury responses in mammals.

The Simon lab's primary salamander model is the Iberian newt which has the widest spectrum of regeneration capacity among vertebrates. The lab has established several experimental paradigms both in vivo and in vitro, sequenced the genome of the Iberian newt, established stable transgenesis, and created genome-edited newts. Harnessing these technological developments, the group is combining exhaustive cell tracking studies with massive parallel sequencing and molecular manipulations to gain insights into regulatory mechanisms whose appropriate targeting could impose regenerative traits to mammals.

Your mission

The postdoctoral fellow will work on spinal cord regeneration with special focus on establishment and re-organization of neural networks during regeneration.The fundamental questions addressed in the project are outlined in Ryczko, Simon, Ijspeert, 2020, Trends in Neurosciences and references within. The successful candidate will be part of a highly interactive multinational and multidisciplinary team and work closely with other lab member to analyze `omics data from regenerating tissue. Such data includes but is not limited to single-cell RNA sequencing, scATAC sequencing, and spatial transcriptomics.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

We are seeking an ambitious postdoctoral fellow with a background in handling and interpreting spatial and single-cell RNA sequencing data. The group is highly international and the working language is English. The candidate’s personal skills will be highly valued.

Preferred skills are:

Proficiency in R/Python
Previously worked with high performance computers (HPC) and in Linux-based environments
Prior analysis of next generation sequencing data such as, bulk RNAseq, single-cell RNAseq, spatial transcriptomics (10x Visium), ATAC seq, whole exome sequencing.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Stockholm

Application

An employment application must contain the following documents in English or Swedish:

Application letter
A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications

Welcome to apply at the latest February 16 2022.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all