Postdoctoral Researcher in neuronal GPCR signalling

Do you want to contribute to top quality medical research?

The Svenningsson lab is a translational and multidisciplinary research group studying movement disorders, particularly Parkinson’s disease, and depression. We use cellular and animal models and analyse samples and biopsies from patients. Our goals are to understand the molecular mechanisms underlying disease states, and to identify novel biomarkers and medically relevant therapeutic targets. At the clinic, we do longitudinal studies on cohorts of patients with Parkinson’s disease and other movement disorders, assessing both motor and non-motor symptoms. We also perform clinical trials with novel pharmacological therapies.

Your mission

We are looking for a highly motivated postdoc, with an interest in translational Neuroscience and a strong background in cellular and molecular biology to be involved in one or more projects investigating the molecular mechanisms underlying Parkinson’s disease and its treatments.

Read some of our recent papers.

The postdoc will use molecular biology methods to develop assays and cellular models for studying molecular events underlying parkinsonism and its treatments involving GPCR- and signalling-mediated approaches.

We expect the successful candidate to be able to significantly contribute to the planning and management of their project(s), as well as to the writing of manuscripts and navigation of the peer-review process.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Requirements

PhD degree in pharmacology, molecular biology or equivalent
Expertise in BRET
Documented experience in molecular biology techniques, such as molecular cloning, western blot, mammalian cell culture and plate reader-based assays such as split luciferase and similar
Broad knowledge of GPCR and cellular signalling
Extensive experience in data analysis and data presentation
High level of motivation and independency
Work well with others in a team
Willingness to supervise or share experience with students
Fluent English in writing and speaking

Merits

CRISPR/Cas-9
Signal transduction assays
Fluorescent, confocal and live cell microscopy

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-02-01.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all