Postdoctoral Researcher in sympathoadrenal malignancies

Do you want to contribute to top quality medical research?

The Schlisio lab at Karolinska Institute, Sweden, seeks a postdoctoral fellow to work on molecular principles of tumor formation arising from the sympathoadrenal cell lineage (neuroblastoma, pheochromocytoma, paraganglioma) to explore cell of origin, disease initiation and tumor heterogeneity.

Your mission

We are seeking a motivated, creative post-doctoral candidate interested in in sympathoadrenal malignancies, such as neuroblastoma (NB) and pheochromocytoma (PCC), with the aim to understand the molecular principles of these tumors at a previously unprecedented level. The neuroblastoma cell of origin is thought to be a developing sympathoblast, however, its precise cell of origin remains unknown. Single cell transcriptomics will identify gene expression clusters that are prominent in specific embryonic sympathoadrenal developmental stages in NB and PCC. Identifying the cell(s) of NB/PCC origin and their temporal development will provide mechanistic insight into: disease initiation, heterogeneity, progression, clinical behavior and spontaneous NB regression. The project involves novel neuroblastoma and pheochromocytoma animal models and cell lines to investigate the dynamics of tumor formation in a single cell mode to compare events in the early tumor with already defined trajectory. This approach may explain the role of known mutations and will help to devise new tumor-differentiating strategies in vivo.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

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