Postdoctoral Researcher: Regulation of human NK cell differentiation - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

Karolinska Institutet, Department of Medicine, Center for Hematology and Regenerative Medicine

We are seeking a highly motivated and ambitious individual to join the research group of Yenan Bryceson as a Postdoctoral Fellow to further elucidate primary immunodeficiency diseases and decipher the molecular regulation of human NK cell differentiation and memory. Our ambition is to develop future research leaders.

Your mission

Previously considered an arm of the innate immune system, recent studies from our group (Schlums, et al., Immunity 2015; Schlums, et al., Blood 2017; Wu et al., Sci Immunol 2018; Holmes et al., Sci Immunol 2021) as well as others have uncovered distinct NK cell differentiation and memory processes. We seek further understanding of NK cell development and immunological memory, which can explain life-threatening primary immunodeficiency disease (PID) syndromes and can be harnessed for cellular immunotherapy of cancer. A successful postdoctoral candidate will be involved in PID diagnostics and exploring novel molecular aspects of human NK cell biology, derived from insights from studies of primary immunodeficiency patients as well as transcriptional and epigenetic analyses. Methods will include advanced flow cytometry and sorting, analyses of chromatin structure and epigenetic modifications, single-cell RNA-seq, genetic manipulation, and functional analyses.

The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers within hematopoiesis and immunity in Europe. The laboratory offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. You can benefit from access to state-of-the-art core facilities at Karolinska Institutet. In the Bryceson group (http://www.ki.se/en/medh/yenan-bryceson-group), you will be working in a very international and interdisciplinary research environment, where collaborative efforts are encouraged.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Entry requirements, skills, and personal qualities

Qualification requirements

• PhD or MD-PhD degree with previous research experience
• First authorship papers in high-ranking, peer-reviewed journals
• Fluent oral and written communication skills in English

Skills that count in the assessment

• Experience in using a variety of molecular biology technologies
• Experience in using a high-throughput sequencing, transcriptomics, epigenetics
• Experience working with primary cells
• Knowledge of lymphocyte biology
• Knowledge and experience of bioinformatics
• Personal fit

Personal qualities

• Hard-working and driven
• Organized
• Self-directed and independent
• Creative
• Collaborative, team player

Duties and work tasks

• Elaboration of scientific hypothesis, experimental design
• Flow cytometry analysis and sorting
• Design and conduct transcriptional and epigenetic analyses
• Presentation and publication of results

Terms

This is a full-time fixed-term appointment for 12 months, with possibilities for extension depending on scientific progress. Positions are available immediately, offering competitive fellowships.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

The department of Medicine in Huddinge 

Center for Hematology and Regenerative Medicine

Yenan Bryceson group

Application

An employment application must contain the following documents in English:

• A letter of motivation explaining the interest in the position and including a summary of why the applicant’s background and experience would be relevant for the project.
• A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work.
• A complete list of publications.
• A synopsis of current research work (no more than one page).
• Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline).

Welcome to apply at the latest 2021-11-26.

The application is to be submitted through the Varbi recruitment system.

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