Research Specialist in projects focused on Notch signaling in the vasculature - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

A position as a Research Specialist is available in the lab of Urban Lendahl at the department of Cell and Molecular Biology at Karolinska Institutet. The lab is located at Neo, KI Flemingsberg, a newly opened research building with excellent infrastructure and world leading research.

Description of the subject area

The Lendahl laboratory is interested in the Notch signaling pathway in various organ systems and how dysregulated Notch signaling leads to disease, including diseases of the vasculature such as CADASIL. We use several different approaches to study Notch signaling, including transgenic mouse reporter gene and gene knock out models, various cell and molecular biology technologies, and single cell RNA-sequencing.

Your mission

A position as a Research Specialist is now open in projects devoted to questions concerning the role of Notch signaling in the healthy and diseased vasculature. The project encompasses analysis of Notch signaling in the mouse brain vasculature as well as analysis of Notch-related vascular diseases (CADASIL and other cerebral small vessel diseases) in humans. The project encompasses extensive use of single cell transcription analysis techniques.

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, applicants must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

We are looking for a highly motivated scientist who can collaborate, communicate and function well in a team. The following qualifications are required: Experience of experimental work focused on the Notch signaling pathway and the mouse vasculature. The successful applicant should have knowledge about mouse genetics methods, skills and appropriate certificate for mouse animal work, experience in FACS analysis, single cell transcriptomics, whole genome sequencing (WGS) and histological methods including immunohistochemistry and methods for in situ hybridization, such as RNAscope. 

Very good English oral and writing skills is a requirement.

Previous published work in the area of Notch signaling and vascular biology is a merit.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Neo, Flemingsberg

https://ki.se/en/cmb/urban-lendahls-group

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

A permanent position is initiated by a six months trial period.

The application must be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all