Research Assistant position in Single Cell Genomics - Hiring in process/Finished, not possible to apply

Do you want to do exciting science and contribute to top-quality biomedical research?

A Research Assistant position in Single Cell Genomics is available immediately in the Bienko and Crosetto lab for Quantitative Genome Biology at the Science for Life Laboratory (SciLifeLab) in Stockholm.

• You will oversee the application and further development of a novel method (scCUTseq), which our lab has recently established to profile copy number alterations (CNAs) in single cells.
• You will apply scCUTseq to dissect genetic heterogeneity in tumors and in the brain. In parallel, you will further develop the method, aiming at making it able to detect complex structural variants and probe the three-dimensional structure of the genome.
• You will work in a dynamic research environment focused on basic genome biology, molecular methods development and oncogenomics (https://bienkocrosettolabs.org/). You will work alongside senior scientists, postdocs and PhD students from many diverse fields and backgrounds, having the opportunity to learn new concepts in biology, developing your experimental skills, and fostering your creativity.

Your mission

Our group has a strong track record in developing sequencing based methods for studying genome fragility (BLESS, Nat Meth 2013; BLISS, Nat Commun 2017, and Nat Prot 2020), genomic alterations (CUTseq, Nat Commun 2019) and genome architecture (GPSeq, Nat Biotechnol 2020).

Recently, we have brought to the single cell (sc) level our CUTseq method for high-throughput profiling of copy number alterations (CNAs) and begun applying scCUTseq to investigate genetic heterogeneity in breast cancer and in human brain cells (unpublished).

As a Research Assistant your primary task will be participating to these efforts, by applying (sc)CUTseq in various collaborative projects. In addition, you will have the opportunity to unleash your creativity and further develop our method to detect complex structural variants and genome organization domains (A/B compartments, TADs) in single cells.

You will be trained in both CUTseq and scCUTseq and learn to independently operate our next-generation sequencing (NGS) platforms on a regular basis.

You will work alongside experts in various NGS assays and actively participate in the analysis of the sequencing data that you will be generating, by working alongside bioinformaticians and computational scientists in our group.

Your profile

Are you a technology-driven and creative person? Are you passionate about genomic technologies and want to develop knowledge and skills in the booming field of single-cell genomics? Are you meticulous, attentive to detail and self-critical? Are you fascinated by complex biological problems that have big implications for human health? Then you are the right person!

You are not expected to know how to design and conduct complex experiments (although you are expected to have prior experience in the wet lab), but you are expected to be willing to learn top-quality laboratory work from people with years of experience, and to be constantly willing to improve your skills and performance as an experimentalist.

If you have previously worked with NGS techniques, that’s great! However, we also welcome applications from people without prior experience in NGS who have previously worked with general molecular biology techniques.

In order to be eligible for this position, you must hold a master’s degree in Biotechnology, Biology, Bioengineering, Biomedicine, or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna, SciLifeLab

Application

An employment application must contain the following documents in English:

1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
2. A complete list of publications
3. A summary of current work (no more than one page)
4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

Welcome to apply at the latest 20th of September 2021.

The application is to be submitted through the Varbi recruitment system. In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Want to make a difference? Join us and contribute to better health for all