1-2 Postdoctoral researchers in the field of mitochondrial genetics with special focus on cancer and metabolism

Do you want to contribute to improving human health?

The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease and ageing. Using patient material and different animal models, our overall aim is to get insights into disease pathophysiology and to develop novel treatments.

Your mission

To study the regulation of mitochondrial function with special focus on cancer and metabolism. Mitochondria are essential for cell function and mitochondrial dysfunction has been implicated in a variety of hereditary diseases, age-related diseases and the normal ageing process. Mitochondria also play a central and multi-functional role in oncogenesis: cancer cells display an altered mitochondrial function and an altered metabolic profile, making mitochondria possible targets for treatment of cancer. Using mouse models, biochemistry, molecular biology and modern -omics approaches, the group of Nils-Göran Larsson focuses on understanding molecular processes determining how mitochondrial function is regulated and the role of mitochondria in ageing and disease. The current project aims at understanding mitochondrial regulation and function in the context of cancer metabolism and oncogenesis.

Your profile

Applications are invited from enthusiastic and motivated individuals with a PhD in molecular biology or genetics. Experience in mitochondrial research is not required, whereas experience in biochemistry, molecular biology, mouse genetics and different -omics methods is of advantage. Candidates with a background in bioinformatics are also of interest. Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to work in a team to pursue his/her research. Personal suitability is of great importance when evaluating the applicants.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

The Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, is located at the newly built and modern laboratory Biomedicum at Solna campus of Karolinska Institutet. Our research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mitochondrial metabolism. Patient material (tissues and cells), genetically modified fruit flies (Drosophila melanogaster) and mice (Mus musculus) are used in our studies. We offer an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly founded Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory.

https://ki.se/en/mbb/research-division-of-molecular-metabolism

https://ki.se/en/mbb/people-nils-goran-larsson-group

Location: Biomedicum, Solna/Stockholm

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé (max 2 pages)
A complete list of publications
A personal motivation letter, explaining your research interest (max 1 page)
Contact information of at least two references

Welcome to apply at the latest May 31st 2021.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all