Postdoctoral researcher in environmental medicine – elucidating the role of the aryl hydrocarbon receptor in toxicology vs. physiology

Do you want to contribute to improving human health?

The mission at the Unit of Systems Toxicology is to perform top quality research to understand how different environmental exposures affect human wellbeing, focusing on the impact of chemicals and microbes on epithelial barrier function and immunity. We work with experimental and bioinformatics models and methods, including cells, zebrafish, and different omics analysis. We are now recruiting a Post Doc who will work with Senior Researcher Emma Wincent in a collaborative project related to the impact of chemical exposure on intestinal homeostasis.

Your mission

The project is centered upon delineating detrimental vs. beneficial functions of the aryl hydrocarbon receptor (AHR), with a particular focus on intestinal barrier integrity. Specifically, you will investigate how xenobiotic chemicals interfere with beneficial functions of the AHR on intestinal stem cell differentiation, using recombinant enzymes, colon organoid cultures, and tissue extracts. The project is performed as a collaboration with the research group led by Brigitta Stockinger at the Francis Crick Institute in London, and you are expected to participate in joint research tasks throughout the project period. The position is temporary for two years.

Your profile

We are looking for an ambitious, highly motivated postdoctoral researcher with a solid background in experimental cell biology and/or toxicology. Experience in cell culturing is required. Previous work with enzyme kinetics, chemical exposure and effect analysis, including techniques such as HPLC, qPCR, transcriptomics and metabolomics data analysis is preferable, and experience in organoid cultures and stem cell differentiation can be meritorious.
The candidate must be able to work within a team with scientists from different disciplines and fluency in English, both written and oral, is a requirement.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Wincent research group: https://staff.ki.se/people/emmvin
Institute of Environmental Medicine: https://ki.se/en/imm/institute-of-environmental-medicine

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all