Do you want to contribute to top quality medical research?

Karolinska Institutet, Institutionen för medicin, Huddinge
The Cell and Gene Therapy Group (CGTG) at the Department of Medicine, Center for Hematology and Regenerative Medicine is announcing a postdoctoral researcher position at Karolinska Institutet within the research fields of Immunology, Cancer Immunotherapy, and Gene Therapy.

Center for Hematology and Regenerative Medicine at the Department of Medicine Huddinge
The department of Medicine, Huddinge conducts graduate and post-graduate education, as well as research, within a wide range of the medical field, covering all internal medicine specialties, infectious diseases, and dermatology. The department consists of seven units with nearly 60 research groups, including three research centers. Our ambition is to be the leading department for medical research and education.

Research group 
The Cell and Gene Therapy Group is a multidisciplinary research group with 17 members, including senior scientists, Ph.D. students, technical and biomedical lab staff, and administration at ANA Futura, Campus Flemingsberg, in a translational research environment. This includes research groups involved in hematology, immunology, and cell therapy. The CGTG has internationally recognized leadership in clinical-grade, current good manufacturing practice (cGMP)-compatible manufacturing of cellular and gene therapy applications. We have access to a GMP facility capable of generating clinical-grade cellular and gene therapy products. Furthermore, the CGTG has been involved in a large number of clinical trials, including the first gene therapy clinical trial in Sweden as well as the first Swedish clinical trials assessing the safety of both patient and donor-derived ex vivo expanded NK cells in patients with various malignancies.

Description of the project
The research project will be pre-clinical translational research in cancer immunotherapy focusing on development of gene editing based therapies.

The aim of this project is to elucidate the impact of different chimeric proteins and mutants thereof to understand the role of tonic signaling during haematopoiesis and effector cell differentiation.

The researcher will use their strong knowledge and experience in stem cell biology, cell model development and CRISPR technology to work on in vitro validation aspects of a therapeutic gene editing project. This includes culture and differentiation of induced pluripotent stem cells (iPSCs) and carrying out gene editing experiments to validate target hypotheses.

Key entry requirements and qualifications
We are looking for a highly motivated, structured and scientifically driven researcher with a Ph.D. degree in immunology, cell biology or haematopoiesis, ideally with proven skills in cellular immunology and/or haematopoiesis research. Excellent proficiency in English, both oral and written is required. Applicants should have publications in recognized peer reviewed journals.

The position requires extensive experience in pluripotent stem cell cultures and iPSC reprogramming is a strong merit. Furthermore, experience with multiparameter flow cytometry cell sorting, cell culture, and genome editing is meriting. Experience with CRISPR gene editing and NGS library prep, expertise with liquid handling automation technologies and experience in setting up cell based pharmacological assays are highly desirable. In addition, we believe that the successful candidate will have a strong background in immunology or haematopoiesis.

Excellent communication skills with the ability to present results clearly, work co-operatively as part of a team as well as independently, with strong attention to detail are also essential.
We will accord special weight to academic skills, particularly demonstrated excellence in research. Personal suitability is of great importance when evaluating the applicants.

We are looking for a researcher who has a strong work ethic, passion for solving difficult questions and challenges with the ability to design, plan, perform, and interpret original experiments in an independent and innovative environment. The candidates should have high integrity and be open to the multicultural setting they are going to be working in.

Your profile
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?
Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

Application
An employment application must contain the following documents in English:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A brief letter describing why you want work with us and how you can contribute to the existing knowledge in the lab (no more than one page)
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 2021-05-07.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment According to agreement
Number of positions 1
Working hours 100%
City Flemingsberg
County Stockholms län
Country Sweden
Reference number STÖD 2-1755/2021
Contact
  • Evren Alici, evren.alici@ki.se
Union representative
  • Belinda Pannagel, SACO, Belinda.pannagel@ki.se
  • Elisabeth Henriksson, OFR, Elisabeth.henriksson@ki.se
  • Mari Gilljam, OFR, Mari.gilljam@ki.se
Published 08.Apr.2021
Last application date 07.May.2021 11:59 PM CET

Return to job vacancies