Postdoctoral Researcher in DNA damage and ubiquitin signaling

Do you want to contribute to top quality medical research?

The Department of Cell and Molecular Biology (CMB, https://ki.se/en/cmb/department-of-cell-and-molecular-biology) is one of five departments conducting advanced experimental research under one roof in the new building of Biomedicum, Karolinska Institutet (https://ki.se), one of Europe's largest laboratories with ultramodern facilities. CMB is a department with a strong focus on basic science and conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

Division

The successful applicant will work in a smaller group currently comprising four members. The research team is physically located at the Biomedicum quarter 7A and share lab with four other groups working on different aspects of biology, including genomic integrity/DNA repair, cell cycle regulation, metabolism and protein ubiquitylation. The position is placed in the research group of Olle Sangfelt (https://ki.se/en/cmb/olle-sangfelts-group) and the projects are focused on investigating how ubiquitin ligases controls different regulatory pathways essential for cellular life, in particular cell cycle control, DNA repair and cell motility. The overall goal of the research is to translate basic scientific discoveries to cancer biology and development of novel treatment strategies.

Duties

The projects are centered around functional analysis of ubiquitin ligases in combination with interdisciplinary translational studies and involves collaborations with both national and international researchers. The postdoc will work closely with the group leader to jointly develop and organize laboratory work, including organizing meetings/courses, ordering of lab-related items, introduction of new employees to maintain a high standard of professionalism within research group. The postdoc will carry out independent laboratory work to functionally explore specific ubiquitin ligases regulating critical targets that directly influence cancer ¨driver¨ and ¨escape¨ programs. The postdoc will also aid in biomarker discovery through close collaboration with scientific partners in the field. One important aim of the research is to unravel mechanisms of drug resistance and specific vulnerabilities in cancer that can lead to the development novel therapeutic approaches.

Your profile

The successful applicant will hold a PhD in Cell Biology, Molecular Biology or Biochemistry. We are seeking a highly motivated postdoc with extensive experience in functional characterization of proteins regulating DNA repair/checkpoints, cell cycle and cell motility. Applicants should be able to demonstrate a strong academic record, including publications in well-reputed scientific journals (including first authorships). Documented technological experience in microscopy, protein interaction/activity analysis/screens and regulated gene silencing/overexpression systems, good knowledge in written and spoken English is required. Experience from ubiquitin research, transcriptional regulation, bioinformatics and cancer genetics is an advantage. The candidate should appreciate problem solving and development of new technologies required to bring the project forward but also demonstrate an ability to complete projects within a defined time frame.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of methodological/techniques expertise (no more than one page)
One recommendation letter and names and contact details of at least two references who are familiar with the applicant’s recent research and training.

The application is to be submitted through the Varbi recruitment system.

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