Postdoctoral studies - macrophages in cardiometabolic disease (scholarship) - Hiring in process/Finished, not possible to apply

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The Department of Laboratory Medicine is searching for a post-doctoral fellow to join the Uwe Tietge research group at the Division of Clinical Chemistry to study the role of macrophages in cardiometabolic disease.

Division of Clinical Chemistry
The Division of Clinical Chemistry is carrying out research to elucidate the molecular basis of cardiometabolic disease, integrating basic science, clinical medicine and translational approaches.

Postdoctoral project duties
Cardiometabolic disease is to a large part underlying the vast increase in non-communicable diseases observed in recent years. Particularly relevant for the current project are the components non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) and atherosclerotic cardiovascular disease. Macrophages integrate metabolic and immune responses and thus represent key effector cells for these pathophysiologies.

In the present project, the impact of signal transduction pathways controlling central checkpoints of metabolism on NAFLD/NASH and atherosclerosis will be explored in experiments spanning from cell culture to in vivo models of disease (including bone marrow transplantation and gene transfer with recombinant viral vectors). CRISPR/Cas9 knockout screens and RNA sequencing will be carried out with the aim to discover and map novel signal transduction pathways. These approaches are complemented with lipid biochemistry and mass spectrometry determinations of changes in metabolites.

Entry requirements
To qualify, the applicant should have a background in biomedical sciences with interest- and experience in the work with cell culture as well as with preclinical animal models. Specifically, experience with in vivo studies in disease models is an advantage. Ideally, the candidate should have prior knowledge in bioinformatics (working with large data sets as e.g. generated by RNA sequencing), metabolism, macrophage (patho)physiology, (primary) cell culture, molecular biology and work with recombinant gene transfer vectors. In addition, extensive knowledge of general laboratory techniques such as cloning and qPCR and experience with the CRISPR/Cas9 system is desirable.

We are looking for a highly motivated, structured, enthusiastic and scientifically driven candidate interested in exploring the molecular basis of (immuno)metabolism. The person should exhibit a high degree of independence but on the other hand also value a collaborative approach to science and enjoy working in a team. Good proficiency in English, both oral and written is required.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Location: KI South Campus, Flemingsberg

Read about the Department of Laboratory Medicine
Read about the Division of Clinical Chemistry

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