Bioinformatician - Precision Medicine

Do you want to contribute to improving human health?

We are looking for a passionate bioinformatician interested in developing data analysis tools for the Molecular Tumor Board Portal, a clinical decision support system to guide molecular based medicine in cancer (see here for more details). MTB-portal is a tool to harness research knowledge for patient benefit. The system is used by 7 European comprehensive cancer centers as a clinical and sequencing data repository, a tool for tumor molecular profiles interpretation, and a framework to report results.

The position will be placed in the Cancer proteomics Mass spectrometry research group headed by Professor Janne Lehtiö at Science for Life Laboratory (SciLifeLab). The Lehtiö group is a translational group aiming to improve cancer treatment using multi-omics tumor data analysis. The group members are from various disciplines working as a team to study genes and proteins in the context of biological networks, understand how tumor molecular changes impact the proteome and discover new disease biomarkers to be exploited therapeutically. Scientists and engineers in our group work closely together using a variety of technologies to generate novel knowledge about the biology of the disease and implement tools to support the clinical-decision making in the oncology setting.

Your mission

We seek a highly motivated bioinformatician interested in developing cancer omics data analysis tools for the clinical setting. In detail, the candidate will work in the Molecular Tumor Board Portal, a clinical decision support system that informs the use of non-standard therapies in advanced tumors (https://www.nature.com/articles/s41591-020-0969-2). The candidate will complement the existing team and will be involved in several tasks, including: developing new analytical methods; integrating third-party tools and databases in existing pipelines; establishing standard operating procedures for software release and maintenance; and participating in scientific discussions. Experience in molecular data (genomics, transcriptomics and/or proteomics) is a definitive advantage for this job. Knowledge of back-end systems is not demanded but applicants will be required to be able to collaborate with back-end engineers.

Responsibilities:

Develop new bioinformatic tools for molecular data analysis
Integrate methods and databases into production pipelines
Establish standard operating procedures for software release and maintenance
Support scientific progress focused on translational application

Your profile

Qualifications /Requirements:

Background in bioinformatics or computational biology
Good programming skills (e.g. Python)
Experience in releasing production software and pipelines
Fluent in English language, both spoken and written
Interest in cancer medicine

Mertis:

Experience with back-end infrastructures
Experience with web front-end technology and user experience.
Experience in working with standard operating procedures

Since the position involves close interaction with several researchers, emphasis is placed on personal skills such as:

Very good collaborative skills
Excellent communication skills and analytical skills

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

SciLifeLab is a national infrastructure and research center in technology driven life sciences and Karolinska Institutet is one of the four founding universities for SciLifeLab. The employment is a temporary position (1+1 year) with possibility of extension. We offer a very stimulating and diverse work in a team of very motivated co-workers with expertise in cutting-edge technology.

Location: Science for Life Laboratory in Solna

LehtiöLab

Nature Medicine

Application

An application must contain the following documents in English:

- Application letter

- A summary of current work (no more than one page)

- Curriculum vitae, qualifications and description of previous work

Welcome to apply at the latest the 14th of February.

The application is to be submitted through the Varbi recruitment system.

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