Postdoc in bioinformatics to understand CD8 T cell responses - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several divisions. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. Research in the department has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

The postdoctoral studies will be performed in the lab of Carmen Gerlach (www.gerlachlab.com), which is part of the Division of Rheumatology. Our research is directed at understanding basic cellular and molecular principles governing T cell responses to acute infections and cancer. We strive to understand mechanisms underlying the generation, maintenance and consequences of the heterogeneity within the T cell immune response, with a special focus on CD8 T cells.

The postdoctoral studies will be carried out in close collaboration with the lab of Liv Eidsmo. Research in the Eidsmo lab focus on the role for resident T cells during homeostasis and immunopathology in the human skin. We have recently defined functional subsets of resident T cells and how these cells interact within the natural microenvironment during the inflammatory skin diseases psoriasis and vitiligo. Currently, the lab heads a mechanistic study of a global clinical trial, investigating if resident T cells can act as biomarkers of remission of psoriasis.

The two labs are collaborating closely, hold joint meetings and journal clubs, and are physically located in close proximity to each other at the Center for Molecular Medicine, CMM at the Solna Campus of the Karolinska University Hospital. CMM has computational infrastructure, and provides a local bioinformatics hub/network where bioinformaticians from all research groups within CMM can exchange ideas and expertise.

Your mission

The postdoc will be collaborating with wet-lab scientists in both labs. The postdoc is expected to plan, execute and interpret bioinformatic analyses of primarily single-cell RNA sequencing data obtained from T cell receptor and mRNA sequences through Illumina sequencing of libraries obtained through the 10x Genomics workflow. In addition, the postdoc is expected to perform bioinformatic analyses of other datasets available in the labs, and develop the analysis of T cell barcoding sequence.

Your profile

We are looking for a highly motivated, ambitious and talented person with excellent theoretical background and practical experience in bioinformatics, and genuine interest in T cell immunology. Prior experience in working with 10x-based single-cell sequencing datasets obtained from immune cells is required, as well as previous experience in collaboration with wet-lab scientists. Basic theoretical knowledge of T cell immunology and previous experience with T cell derived sequencing data is highly valued. Excellent communication skills that allow for productive interactions with biologists lacking bioinformatics background will be key. This includes the willingness and ability to explain, justify and discuss analyses/model choices with other lab members and supervisors. The position requires dedication to the project, a high level of accuracy and attention to detail, and a strong desire to excel. A personal fit into the team will be of importance. A proactive and problem-solving attitude will be valued highly. Excellent communication skills in both spoken and written English are required. The candidate should hold a doctoral degree upon the start of this position, and previous postdoctotal experience is a plus.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Carmen Gerlach (www.gerlachlab.com)

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Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

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