Researcher in epigenetic regulation of acute myeloid leukemia (AML) - Hiring in process/Finished, not possible to apply

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, bioorganic chemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

Your mission

We are looking for a Researcher to Andreas Lennartsson´s research group.
The group is focusing on epigenetic regulation of normal myelopoiesis and acute myeloid leukemia (AML), (https://ki.se/en/bionut/epigenetic-regulation-of-leukemia-and-normal-blood-development-andreas-lennartsson).  The aim is to identify key epigenetic factors that regulate multi-potency and differentiation of hematopoietic stem cells and dissect how they contribute to the development of leukemic stem cells. We aim to understand epigenetic dysregulation in AML and to develop new treatment strategies based on epigenetic dysregulation.

The successful candidate´s main task will be to work on three projects: A) Single cell transcriptional drug response in primary AML cells, B) Exploiting cellular stress in sensitizing AML cells for novel treatment and C) The role of long non-coding RNA in AML. You will be responsible for coordinating the projects with involved collaborators, perform, and analyze experiments.

Emphasis will be placed on personal suitability. 

Qualifications

The applicant should hold a PhD from a related area as well as documented research after the defense, with experience in epigenomics of AML. The candidate should have a strong background in molecular biology and biochemistry with focus on AML pathways, ribosomal biology, nucleolar stress, and cancer signaling. Prior experience in single cell transcriptomics with C1 CAGE and lncRNA biology is encouraged. Experience in supervising students is also a strong merit. Candidates should be able to interact and work efficiently in a team. The projects are based on collaboration between different research groups, therefore strong social skills are required. Excellent knowledge of both spoken and written English is essential.

Your profile

A person is eligible to be appointed Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after the defense of his or her doctoral thesis.

Bases of assessment

We stress research expertise when assessing applicants.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

www.bionut.ki.se

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Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: 

-  A letter of motivation
-  Curriculum vitae
-  A complete list of publications

Welcome to apply at the latest 17 February 2021.

The application is to be submitted through the Varbi recruitment system.  

Permanent position are initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all