Do you want to contribute to top quality medical research?

Join a dynamic, supportive research environment in order to address two of the major problems in our aging population, vascular disease and cancer. The projects are based on collaborations between pre-clinical, clinical scientists as well as the state-of-the art technology platforms situated at Sci-Life.

Your mission

Project background

Mechanical forces control the development of functional organs but are also deregulated in tumor progression. To date, we know very little regarding the molecular pathways by which cells respond to force and how these can be used for therapeutics. We have previously reported the discovery of the Angiomotin protein family (Troyanovsky JCB 2001, Aase Genes&Development 2007, Yi Cancer Cell 2011, Hultin Nature Comm 2014, Mojallal Nature Comm 2014, Zheng Scientific Reports 2016). During this granting period, we have shown that these proteins relay force by connecting membrane receptors to the cytoskeleton. We further showed relevance for these proteins in essential developmental processes such as angiogenesis, blastocyst hatching and aortic expansion. We further show that these pathways are deregulated in invasive cancer. The present proposal is based on yet unpublished data regarding a direct mechanical connection between the microenvironment and the cell nucleus. We aim to show how this affects nuclear properties promoting invasion and through the use state-of-the-art techniques to investigate how mechanical forces affect chromatin architecture and gene transcription.

Lars Holmsgren's Group

Area of responsibilities/description of the work

We aim to study the role of the Amot family of proteins in development and cancer. This family of proteins was discovered by the group and has been shown to be involved in cell migration, polarity, cytoskeletal rearrangement and cell-cell contact formation. The successful candidate will be part of a team that studies how mechanical forces affect normal developments as well as the progression of vascular disease and cancer.   More specifically, the molecular mechanisms how mechanical forces are relayed between cells, how this affects morphogenesis, cellular invasion/migration, nuclear positioning and chromosomal organization.

The position is a temporary employment for one year with possibility for extension. 

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

To qualify, the applicant must hold a doctor’s degree or a foreign qualification deemed equivalent to a doctorate in a relevant field. The applicant must have more than 3 years of experience in experimental research and have proven skills in the areas of vascular biology, confocal imaging, in vitro and in vivo transgenic mouse models. Experience in bioinformatics is a plus. The applicant should be fluent in written and spoken English and to be able to work as a member of a team is a must.

The position will be fixed to one year with possibilities for prolongation with one year. Applicants will be evaluated on the following criteria:

1)  Education and previous training

2)  Relevance for the project

3)  Publication and track record

4)  Motivation

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.


Location:
Department of Oncology and Pathology, Bioclinicum, Karolinska Institutet, Solna.

Department of Oncology-Pathology

Lars Holmgren

 

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 2020-12-09.

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Type of employment Temporary position
Contract type Full time
First day of employment 2021-01-01
Number of positions 2
Full-time equivalent 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number STÖD 2-5106/2020
Contact
  • Lars Holmgren, lars.holmgren@ki.se
Union representative
  • Helen Eriksson, OFR, 08-524 823 38
  • Andreas Lundqvist, SACO, 08-517 768 84
Published 26.Nov.2020
Last application date 09.Dec.2020 11:59 PM CET

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