Do you want to contribute to top quality medical research?

Are you interested in non-genetic cellular heterogeneity and their role in disease? Would you like to contribute to the development of cutting-edge genome-wide technologies?  Come and join us at SciLifeLab.

Division

The Department of Microbiology, Tumor and Cell Biology conducts research and teaching in immunology, infection biology, cell biology and cancer. Our laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus.

SciLifeLab is equiped with state-of-the-art instrumentation and core facilities and is home to the second largest sequencing cluster in Europe. SciLifeLab Stockholm is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH) and Stockholm University, and hosts research groups with diverse backgrounds and expertise, including basic biology, drug discovery, genomics, bioengineering, and translational medicine.

The group

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

Duties

The available postdoctoral position concerns developing and applying novel approaches to study cellular plasticity at single cell level. The candidate will focus on the development of CRISPR based screens and other advanced genome-wide approaches to investigate factors controlling single cell phenotypic plasticity and drug resistance. This will include bulk and single-cell approaches such as RNA-Seq or ATAC-Seq, and novel technologies developed at our laboratory.

The candidate is expected to contribute his/her own ideas to the common goal of understanding how gene expression variability contributes to the appearance of divergent cellular phenotypes. The candidate will perform original research in molecular biology, cancer biology and genomics, and acquire the required experimental and computational skills necessary for the completion of the project. The successful candidate will take a strong lead in the experimental and computational design, and collaborate with other team members.

The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.

The candidate will work in a team funded by an ERC evaluated/Swedish funded grant (http://startinggrant.se/) and a Wallenberg Academy Fellowship 2016 to Vicent Pelechano (http://kaw.wallenberg.org/en/wallenberg-academy-fellows-2016).

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Applicants to this position should have a PhD in cancer biology, genomics, or molecular biology.

The successful applicant to the current position should have experience interpreting biological data and experimentally testing their hypothesis. Previous experience in cancer biology, CRISPR technologies and epigenetics will be highly considered. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential.

Preferred experience also includes familiarity with cancer biology, tissue culture, genome editing, ChIP-Seq, ATAC-Seq, bioinformatics, and molecular biology techniques. This is an excellent opportunity for an individual with experience in cancer biology and epigenetics to expand his/her ability to genomics. Applicants wishing to integrate computational and experimental biology approaches are also encouraged to apply.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Location: Solna

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Last day of application is: 2020-10-16

Want to make a difference? Join us and contribute to better health for all

First day of employment According to agreement
Salary Monthly Salary
Reference number STÖD 2-3989/2020
Contact
  • Vicente Pelechano Garcia, vicente.pelechano.garcia@ki.se
Union representative
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Gunnel Brolin, OFR, gunnel.brolin@ki.se
  • SACO, saco@ki.se
Published 23.Sep.2020
Last application date 16.Oct.2020 11:59 PM CET

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