Postdoctoral Researcher in epigenetics of neuroinflammation

Do you want to contribute to top quality medical research?

The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The successful candidates will work in Assoc. Prof. Maja Jagodic’s research group, physically located at the Center for Molecular Medicine (CMM). The group is a part of the Karolinska Neuroimmunology and Multiple Sclerosis (KNIMS) center which gathers around 50 researchers working on different aspects of the pathogenesis of Multiple Sclerosis (MS), including genetics, epidemiology, immunology and epigenetics, with excellent clinical cohorts and experimental models. The group studies epigenetic mechanisms underlying neuroinflammation and neuronal loss in MS using both largescale omics approaches and molecular in vivo and in vitro functional experiments.

We are looking for two postdoctoral researchers who share our passion for translational epigenetics, are ready to join our very collaborative team, and are highly motivated to perform both computational and molecular work. The positions are funded through the European Research Council (ERC-CoG) and the Knut and Alice Wallenberg foundation grants.

Your mission

MS is an immune-mediated disease triggered by complex interactions between genetic and environmental risk factors resulting in a highly heterogeneous disease with respect to its clinical presentation and treatment response. We are looking for postdoctoral researchers who will develop and implement molecular and analytical/bioinformatics approaches to study molecular mechanisms underlying disease susceptibility and progression, focusing on multi-omics level down to single-cell analysis. The work will include design of experiments and analysis, data processing, quality control, statistical analysis, data interpretation and presentation of findings in the form of scientific publications, grant applications and at meetings and conferences. The candidates are expected to interact with many collaborators at KI and externally and to contribute to the efficient functioning of the unit.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Absolute Requirements

Documented knowledge of neuroinflammatory and neurodegenerative diseases
Documented research experience of complex e.g. multi-omics data analysis
Demonstrated skills in molecular biology, in particular DNA methylation and RNA analysis
Experience and competence in scientific computing including skills in at least one language (preferably R language)
Experience and competence in NGS/array technologies
Documented knowledge of statistics
Familiarity with the FAIR principle (findable, accessible, interoperable and reusable)
Good knowledge of spoken and written English

Preferred Requirements

The candidates should also have good interpersonal skills and the ability to work both independently but also as a part of a large team. In addition, good communication skills are desirable. Experience with writing scientific papers and experience with writing grant applications is a merit. Experience with single-cell, or other types of low input, genomics methods and analysis is an advantage.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 1st of May 2020.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!