Postdoctoral Researcher in brain vascular biology - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

The Division of Neurogeriatrics is focused on translational research in neurodegenerative diseases, in particular Alzheimer disease. The labs of Helena Karlström and Per Nilsson focus on Small vessel disease/CADASIL and Alzheimer’s disease. In a fruitful collaboration we investigate the relationship of impaired vascular function and brain diseases.

Your mission

Both Alzheimer’s disease and CADASIL are characterized by impairment of the vasculature and changes in the blood vessel composition.  The pathological changes are anticipated to contribute to disease development and potentially also oppositely be affected by the pathologies present in the diseased brains. The candidate will work in a collaborative effort to delineate the role of the vasculature in the development of Alzheimer disease and CADASIL using state-of-the-art CADASIL and Alzheimer mouse models. The candidate will work within a larger team comprising both preclinical and clinical researchers which together with bioinformaticians will perform single cell RNA sequencing of the vascular cell populations in human diseased brains and animal models. These scRNA data, including comparison of human and animal data, will form the basis for the follow up characterization of the vasculature in CADASIL and Alzheimer mouse models, using a battery of techniques such as immunostaining of microvasculature, RNA scope and different protein analysis methods.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

The applicant needs to have good communicative capabilities since the work is collaborative with the base in Karlström Nilsson labs. Good ability to speak and write English is also a requirement. A strong scientific drive is expected, documented with a publication record. The successful applicant should have extensive experiences and practical skills from research animal work, cell-and molecular biology techniques such as RNA scope, immunohistochemistry and regular protein analysis methods. Previous research experience from neurodegenerative diseases/neuroscience is a merit.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: BioClinicum, Karolinska Institutet, Solna Campus

https://ki.se/en/nvs/research-at-the-division-of-neurogeriatrics

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2020-04-30

The application is to be submitted through the Varbi recruitment system.

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