Post-doctoral studies in tRNA informatics and biology

Do you want to contribute to top quality medical research?

The Ola Larsson’s research group is searching for a post-doctoral fellow to perform cutting edge research joining tRNA biology and mRNA translation. The research environment is dynamic and multidisciplinary with both wet-lab and dry-lab components which vigorously interact to generate new knowledge. This fellowship will allow the accepted applicant to gain a set of unique insights into how gene expression is regulated and to drive discoveries facilitating future improvements of population health.

Your mission

This project involves applying state of the art-methods for global studies of mRNA translation and tRNA expression/modifications and downstream analysis and integration of large data sets. The goal is to understand tRNA biology in general and how it can underly human pathology. In particular, there will be a focus on understanding how dynamic changes in tRNA properties steers biological responses by modulating mRNA translation. The model systems will include both cancer and malaria. The successful applicant will perform wet-lab experiments to generate transcriptome-wide insights in mRNA translation as well as tRNA expression and modifications. The applicant is also expected to analyse the generated data set to identify links between tRNA expression/modifications and changes in mRNA translation which will potentially impact cellular phenotypes. The generated hypotheses will then be tested using systems biology approaches involving data-driven hypothesis refinement. Therefore, the ideal candidate will be proficient both in RNA molecular biology as well as analyses of large scale sequencing data set using e.g. R.

Your profile

The ideal applicant has a background in RNA molecular biology and analyses of large scale sequencing data sets. Specific knowledge in mRNA translation and tRNA biology is an advantage. Fluency in English is required. The applicant is expected to have published at least one paper containing primary research in a well-recognized journal as first author.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

https://ki.se/en/onkpat/ola-larssons-group

https://ki.se/en/onkpat/department-of-oncology-pathology

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 7th of January.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all