Postdoctoral Researcher in Characterization of autoreactive T-cells in multiple sclerosis - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

Within our research groups you will find a unique option to work closely together with cutting edge researchers in the intersection between immunology genetics and neurology. We offer an engaging and international research environment where you may contribute to high quality research on an internationally competitive level.

Your mission

This postdoctoral project relates to autoreactive T-cells identified in multiple sclerosis with a new immunological method. It is mainly comprised of two parts:

1. Deeper characterization of autoreactive T-cells specific for the novel autoantigens from patient and control samples using a combination of the established methods as well as T-cell proliferation assays and flow cytometry analysis. The exact methods regarding the proliferation and FACS will have to be, at least partly, developed during the project. The goal will be both on identifying potential MS-selective T-cell phenotypes such as CD4+, CD8+, Th1/2/17, effector-/memory-cells and cytokine/chemokines and receptors, as well as confirm previous FluoroSpot results regarding autoreactive T-cell frequencies.

2. Investigate the autoreactive profile of CNS-infiltrating T-cells. In these experiments, previous established FluoroSpot methods are not adequate as the antigen-presenting cell population is essentially absent in samples form the CSF. Modification of existing methods will have to be performed in order to effectively be able to analyze these types of cells.

The employment is for two years, with the possibility of an extension of two years.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Knowledge requirements:

• Advanced immunology, focus on T-cell immunology and functions
• Autoimmunity, preferably regarding multiple sclerosis

Skill requirements:

• Experienced in cell-lab work, mainly handling human cell samples and T-cell cultures
• Flow cytometry
• Method development
• Knowledge in English is sufficient

Finally, the person should be able to work in an independent way and work in a cooperative manner. A good communicative capacity is important.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location:

Hans Grönlund´s and Tomas Olsson´s team, being parts of the Department of Clinical Neuroscience, located at the Center for Molecular Medicine Karolinska Hospital (Solna).

Read more about the research group you will be part of here :

https://www.cmm.ki.se/web/guest/tomas-olsson-group1

https://www.cmm.ki.se/web/guest/hans-gronlund-grupp

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 17th November 2019.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all