Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Vascular Biology

The lab and technologies
The Jakobsson lab investigates processes of blood vessel morphogenesis and function in development and disease, with the aim to develop new therapies. The lab utilizes mouse models of human disease based on inducible genetic loss- and gain- of-function in combination with state-of-the-art confocal live imaging (multi-photon, in vivo and ex vivo). In addition the environment provides access to drug screening platforms, proteomics and single cell RNA sequencing. The lab has an extensive international scientific network and is integrated in a highly interactive scientific environment with close contact with the clinic. Recent publications from the lab:

 Jin et al, Nat. Cell Biol., 2017; Wang et al, Development, 2017; Wang et al, Sci. Rep., 2018

The project
The lab aims to find novel ways of modulating angiogenesis and vessel function. The studies build on the lab’s previous findings on endothelial cell- signaling, behavior and gene expression in vascular patterning and malformation in the CNS. The project will focus on mechanisms of establishment of arteries and veins and maintenance of vessel function in relation to human disease. Data acquisition is facilitated by novel mouse models in combination with abovementioned technologies, including single cell RNA seq. Please visit the lab website (http://ki.se/en/mbb/lars-jakobsson-group) for an overview.

The Department and location
The Department of Medical Biochemistry and Biophysics at Karolinska Institutet conducts a broad spectrum of biomedical research and education at the absolute forefront. Presently our department consists of 12 research divisions with a total of approximately 450 employees. The postdoc will work in Dr. Lars Jakobsson’s group at the Division of Vascular Biology, located in a vibrant environment in a brand new research center, Biomedicum, in central Stockholm. Please see Biomedicum Stockholm

Who would we like to attract?
We are looking for a highly motivated, creative and interactive sharp mind with a passion for understanding biology in depth.

Qualifications
To qualify, the applicant:

  •  must hold (or shortly obtain) a doctor’s degree, acquired no later than two years prior application deadline, in the fields of molecular/ developmental biology, biotechnology/engineering or similar.
  • Previous engagement in developmental biology, vascular biology or neuroscience with experience of confocal microscopy and/or image analysis, in vivo experimentation, tissue culture, cell signaling, cloning and bioinformatics would be an advantage.
  • A strong publication record
  • The candidate should be self-motivated and driven, with good communication skills.
  • A high level of English, spoken and written, is a requirement.

Type of position
The postdoc position is available immediately. Funding, in the form of a scholarship is tax-exempt and ranges between 25 000 to 28 000 SEK/month. This funding is provided for a maximum of two years, with a possibility for extension of another two years on complete salary scheme. 

Application process  The application should contain the following documents (no additional information required initially) in English:

  • Curriculum vitae, including thesis title and date of defense.
  • A complete list of publications, including submitted work.
  • Letter of motivation (explaining research interests an expertise.

The application is to be submitted through the Varbi recruitment system, or directly sent to Lars.jakobsson@ki.se .

Type of employment PhD placement
Contract type Full time
Number of positions 1
Working hours 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-357/2019
Union representative
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75 , biborka.bveress@ki.se
  • Anne Edgren, OFR/S, P, O, 08-524 87570
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 17.Jan.2019
Last application date 17.Feb.2019 11:59 PM CET

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