Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Translational Medicine and Chemical Biology

The Bienko Laboratory for Quantitative Biology of the Nucleus (http://bienkocrosettolabs.org) at Karolinska Institutet (www.ki.se, ranked 9 in 2015-2016 QS) is located at SciLifeLab (www.scilifelab.se), an interdisciplinary center for biosciences bringing together researchers from four different universities and providing top-notch facility services to scientists all over Sweden. The Bienko Lab’s main goal is to unravel the fundamental design principles that govern the three-dimensional organization of the mammalian nucleus. To achieve this, the lab combines high-end microscopy techniques (DNA and RNA FISH) and next-generation sequencing methods (HiC, BLESS, in-house methods) with advanced mathematical tools (topological data analysis) in a thriving interdisciplinary atmosphere.

A position (postdoc level) is available for an NGS pipeline manager that will be responsible for the implementation and maintenance of standard, as well as ad hoc pipelines for processing the NGS data that are generated in the Bienko Lab using both published methods (e.g., HiC) as well as new in-house methods for measuring DNA accessibility, conformation, and fragility. Other tasks include: 1) supporting group members with statistical interpretation of NGS data; 2) basic training in Unix scripting and Python programming for experimenters in the group; 3) analysis of NGS data generated in the frame of collaborative projects.

Qualifications
The candidate should have very strong programming skills (proficiency in C++, Python, R and Unix) and a solid publication record in the field of NGS data analysis, preferably with prior experience with data generated by methods for genome-wide profiling of DNA accessibility (e.g. DNAseI-seq, ATAC-seq) and/or chromosome conformation (e.g. HiC, 4C) and/or gene e.g., RNA-seq, GROSeq). A background in statistics and expertise in statistical methods for interpreting NGS data is a strong plus.

To apply
The application is to be registered in MyNetwork. Please attach motivation letter together with a complete CV, a full list of publications, and the contact details (name, institution, email) of two referees.

About scholarships
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Type of employment Postdoctoral scholarship
Contract type Full time
Reference number 2-4202/2016
Contact
  • Magda Bienko , +46 (0)8-524 800 00
Union representative
  • Anne Edgren, OFR/S, P, O, +46 (0)8-616 16 29
  • Biborka Bereczky Veress, SACO, +46 (0)70-173 85 75
  • Henry Wölling, SEKO, +46 (0)8-524 840 80
Published 07.Nov.2016
Last application date 28.Nov.2016 11:59 PM CET

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