Postdoctoral Researcher for the H2020 project DECIDER - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

A postdoctoral position within a collaborative and exciting new H2020 project DECIDER (https://www.deciderproject.eu/) that focuses on overcoming chemotherapy resistance in high-grade serous ovarian cancer is immediately available in the laboratory of Professor Jussi Taipale who heads research groups at Karolinska Institutet, University of Cambridge and University of Helsinki. This position is based at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet.

Research group

The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology and as such the research groups consist of both experimental biologists and computer scientists. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer and validation of identified elements using cultured cells and mouse genetic models (see for example Hallikas et al., Cell 124:47-59, 2006; Kivioja et al., Nature Methods 9:72-74, 2011; Sur et al., Science 338:1360-1363, 2012; Jolma et al., Cell 152:327-339, 2013; Yan et al., Cell 154:801-813, 2013; Jolma et al., Nature 527:384-388, 2015; Yin et al., Science 356: eaaj2239, 2017; Zhu et al., Nature 562: 76-81, 2018; Jolma et al., Genome Research 30: 962-973, 2020; Yi et al., Nature Methods 17: 685-688, 2020). The applicant benefits greatly from knowledge and expertise of a lab working at the cutting edge of science.

Your mission

The goal of the project is to identify the regulatory processes that cause chemotherapy resistance of cancer cells. The successful candidate will map the gene expression profile at a single-cell resolution to uncover how different drug-responses are mediated by distinct clonal subpopulations within a tumor and thereby define the changes associated with drug-resistance. These results will be used to discover predictive biomarkers for clinical response.  The project requires that the applicant has excellent skills in lab work and is familiar with computational analysis of experimental data.

Your profile

The successful candidate should be highly motivated and have a doctoral degree or a foreign qualification deemed equivalent to a doctorate in Systems Biology, Molecular Biology, Biological engineering, Medicine or similar along with computational experience for analysing large sets of data. Applicants with strong backgrounds in molecular biology/bioinformatics who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. We also encourage applications from those who expect to complete their PhD within one year from current date and those who have completed their PhD less than 12 months ago. Applicants must be able to work independently and have good communication skills in English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Biomedicum, Solna

(https://www.taipalelabs.org/)

Application

An employment application should be a maximum of 7A4 pages in total and must contain the following documents in English:

• One-page cover letter highlighting your 2 most important first-author publications in major international scientific journals
• Two-page CV including a list of major publications (reference only, no abstracts or full papers)
• Two letters of recommendation, 1-2 pages each

Welcome to apply at the latest 2nd of April 2021.

The application is to be submitted through the Varbi recruitment system.

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