Postdoctoral position on colorectal cancer tumor microenvironment

Do you want to contribute to top quality medical research?

Our research team is seeking an ambitious postdoc to develop an exciting project on new subsets of human cancer-associated fibroblasts, identified by single cell RNA sequencing, with focus on their in situ interactions with cancer cells and immune cells, and associations with outcome. This dynamic project involves most advanced methods for spatial tissue profiling and associated image analyses. An aspect adding value to the project are a series of collaborations with clinical partners with colorectal cancer expertise and image analyses experts.

Your mission

The position will be placed in Prof. Arne Östman's research group. The Östman group has for more than 15 years performed translational research on the tumor microenvironment. Studies span the range from tumor biology studies, experimental therapy studies and tissue profiling for discovery of prognostic and predictive biomarkers.

Östman group is part of Department of Oncology-Pathology. Activities at the department include basic, translational and clinical research and education related to cancer. Approximately 300 people from over 40 nations are currently working at the department. The department have 37 research groups and around 110 PhD students.

The candidate will perform a broad spectrum of studies, including continued in situ analyses of distribution and spatial context of recently identified subsets of colon cancer fibroblasts.

Studies will possibly also be extended to experimental work involving co-culture-based cell culture work and use of mouse cancer models.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

The applicant must show verified skills particularly in in tumor biology, preferably with a focus on tumor microenvironment and antibody-based tissue analyses. Candidates with experience with big data analyses, and coding with R and/or Python are prioritized.

The candidate should be self-motivated, have good communication skills and an ability to interact effectively and work within a team. Fluency in English is a requirement.

The position will be paid as a salary, the amount of which depends on the background of the applicant.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest March 15.

The application is to be submitted through the Varbi recruitment system.

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