Postdoctoral position in RNA editing in health and disease - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

New research area, new opportunity! Join us for studying RNA editing in health and disease!

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Your mission
The selected postdoctoral candidate will work in our multidisciplinary team of researchers including clinicians, molecular biologists and bioinformaticians, and will be supervised by Prof. Qiang Pan-Hammarström at Karolinska Institutet (KI). The postdoctoral study will be primary based in KI, but will have possibilities to visit Broad Institute in Cambridge for additional training in technology and bioinformatics.

The main tasks for the successful candidate are:

1) Characterization of RNA editing events in cells from healthy individuals as well as from disease models using next generation sequencing technologies. The disease models include B cell lymphoma, primary immunodeficiency and infectious disease such as Covid-19.
2) Validation of RNA editing events by site-specific modification using the Cas13-based RNA editing system.
3) Develop new therapeutic approaches based on RNA-editing technologies.
4) The postdoctoral candidate is expected to assume a major role in the writing of scientific publications and grant applications and contribute to supervise PhD and master students in the group.

Qualifications
We are seeking a highly skilled and motivated candidate who are interested in applying new technologies and tools for understanding the mechanisms underlying human diseases and for development of novel therapies for patients. The applicant should have been awarded a PhD or equivalent degree in medicine, biotechnology, immunology, genetics, cancer biology, molecular biology, infectious disease or areas relevant to the announced position. He/she should have achieved the corresponding scientific competence, with first-authored publications in internationally leading journals in the corresponding fields. Extensive research experience in next generation sequencing data analysis and state-of-art molecular and cellular biology techniques is required. The applicant must be able to work productively via collaborative interactions with team members. Furthermore, the candidate should possess excellent communicating and writing skills in English.

Bases of assessment
We stress scientific excellence and potential when assessing applicants. The applicants’ track record based on curriculum vitae and bibliography will be assessed. Evidence for independence, innovation and the capacity to work and publish in a multidisciplinary environment is weighted in ranking the applicants. Reference letters will be requested from the PhD supervisor(s) and considered from selected candidates.

Your profile
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Flemingsberg

Type of employment Full time position for 2 years, with a possibility to extension

https://ki.se/en/bionut/research-group-qiang-pan-hammarstrom

Application
An employment application must contain the following documents in English:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)
• Two recommendation letters, including at least one from the PhD supervisor

The application is to be submitted through the Varbi recruitment system.

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