Postdoctoral studies in Stem Cell Biology using single-cell and spatial transcriptomics (scholarship)

Do you want to contribute to top quality medical research? 

Our lab addresses fundamental questions in stem cell biology, including how stem cells generate diverse neurons and glial cells during fetal development, maturation, aging as well as under specific disease-associated mutations. By using single-cell and spatial transcriptomics on both human and rodent brain and spinal cord tissue, we have generated different atlases across diverse conditions (development, aging, disease etc.), and established various bioinformatic pipelines, cell and animal models for relevant analyses and validation. We aim to elucidate the molecular and cellular mechanisms for cell fate specification during differentiation, and leverage this new knowledge for therapeutic possibilities, in the context of neurodevelopmental diseases, neurotrauma, and brain tumors.

The project for the future postdoc will be under the supervision of Assistant Professor Xiaofei Li, with a combination of single-cell and spatial omics techniques, bioinformatic analysis, and cell and molecular experiments to address how stem cells are genetically regulated during development, aging and under degenerative conditions in the central nervous system.

Division

The Division of Neurogeriatrics consists of about 65 employees. The division conducts experimental and translational research related primarily to different neurodegenerative diseases, but more general molecular mechanisms of biomedical relevance are also studied.

Duties

A postdoctoral position is now open in projects devoted to study the genetic regulations during neurodevelopmental diseases as well as aging.

The postdoctoral fellow is expected to play a key role in experimental design, experimentation, analysis, as well as presentation/publication of results.

Entry requirements

The applicant should be a highly motivated individual who can collaborate and function well in a team. We are looking for a person who holds a PhD in the field of bioinformatics, or cell and molecular biology with a strong background in data analysis, with documented skills in R or Python programming. The candidate should also have interest in neuroscience/ stem cell biology, and with skills preferably in more than one of the following areas: R or Python programming, bioinformatic analysis for single cell RNA-sequencing and/ or spatial transcriptomics data, cell biology, genetics, statistics, and histological methods. Previous experience of analyzing large-scale datasets is meriting. Excellent English oral and writing skills is a requirement.

Postdoctoral scholarships may be established for foreign researchers who pursue their postdoctoral research in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location: Stockholm (Solna)

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

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