Postdoctoral Researcher in: “Functional Genomics of Parkinson’s disease” - Hiring in process/Finished, not possible to apply

Do you want to contribute to improving human health?

We invite applications for a postdoctoral position in the laboratory of Professor Ernest Arenas: http://ernestarenaslab.org/. The position will be placed in the Division of Molecular Neurobiology, a cluster of 7 research groups forming a dynamic and collaborative research environment within the MBB department.

Our laboratory is located in the Biomedicum building, one of the most modern research centers in Northern Europe, within a world leading University, Karolinska Institutet. Our lab offers an inclusive, interactive, multidisciplinary, international research work environment, where you can develop your career and do science that can make a difference.

Your mission

We look for postdoctoral interested in working in a project aiming at: (i) identifying the function of genes associated to the risk of suffering Parkinson’s disease using CRISPR/dCas9 strategies and dopaminergic neurons derived from human pluripotent stem cells, (ii) assessing the contribution of these genes to disease phenotype in PD-iPS cells, and (iii) developing strategies to correct phenotypic abnormalities in PD-iPS cells.

The project is based on our recent characterization of (i) the cellular and molecular complexity of the developing mouse and human midbrain at the single cell level (La Manno et al., Cell, 2106), (ii) the identification of cell-types associated to the genetic risk of PD, as assessed by combining single cell RNA-seq data and genome-wide association data (Bryois et al., Nature Genetics, 2020), and (iii) ongoing studies aiming at defining changes in gene expression and chromatin at the single cell level in idiopathic and familial PD.

The successful candidate will participate in all the activities of the lab, including scientific meetings, international networks and education of medical/biomedical students.

Your profile

You are a PhD or a Postdoc with working on Parkinson’s disease, genetics, neuroscience, molecular, developmental or stem cell biology. You have demonstrated skills in molecular and cellular biology, biochemistry, cell-based screens and stem cell culture. The preferred candidate will have previous experience in Parkinson’s disease genetics or cellular mechanisms of PD. Knowledge or experience in genomics, transcriptomics, proteomics, lipidomics, bioinformatics, or drug screening will be an additional advantage. Publications in high profile journals and experience in working in a multidisciplinary international environment will be considered as merits. Applicants should have good communication skills and be proficient in spoken and written English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

We offer a two-year (1+1 year) full time (100%) postdoctoral position starting in 2021. Our laboratory and our division offer a creative, collaborative, interdisciplinary and international research environment, where you will have the opportunity to seek personal development, enjoy science and make a difference.

Location: Solna, Biomedicum

Application

Your application must contain the following documents in English:

1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
2. A complete list of publications.
3. A summary of current work (no more than one page).
4. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).
5. A letter of motivation (no more than one page)
6. Three references or reference letters

In assessing candidates we will place our emphasis on the personal trajectory, education, personal and technical skills, CV, merits and previous experience.

Welcome to apply at the latest 8th of January 2021.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all